| Date | H/A | Opponent | Score | Scorers |
| 20/08/05 | H | Leeds United | 3-3 | Lyons 2. Dayton. |
| 27/08/05 | A | Huddersfield Town | 7-2 | Dayton. Lyons. Peltonen 3. Starkey. Hughes. |
| 03/09/05 | A | Leicester City | 0-4 | |
| 10/09/05 | H | Milton Keynes Dons | 2-3 | Starkey. Reid. |
| 17/09/05 | A | Reading | 3-3 | Dayton. Peltonen. Moses. |
| 24/09/05 | H | Southamton | 1-2 | R Hall. |
| 01/10/05 | A | Fulham | 1-1 | Kudjodi. |
| 08/10/05 | H | Millwall | 1-2 | Lyons. |
| 15/10/05 | A | Arsenal | 0-1 | |
| 22/10/05 | H | Ipswich Town | 4-3 | Smith 2. Lyons. Dayton. |
| 05/11/05 | H | West Ham United | 0-1 | |
| 12/11/05 | H | Charlton Athletic | 4-3 | Spence 2. Dayton. Grabban. |
| 19/11/05 | A | Norwich City | 1-3 | Spence. |
| 03/12/05 | H | Chelsea | 0-1 | |
| 10/12/05 | A | Southampton | 1-7 | Peltonen. |
| 07/01/06 | A | Millwall | 5-0 | Moses. Grabban 3. Own Goal. |
| 21/01/06 | A | Ipswich Town | 3-3 | Grabban. Dayton. Scannell. |
| 04/02/06 | A | West Ham United | 2-3 | Own Goal. Moses. |
| 18/02/06 | H | Norwich City | 1-2 | Watanabe. |
| 25/02/06 | A | Chelsea | 0-2 | |
| 04/03/06 | H | Fulham | 1-2 | Hughes. |
| 11/03/06 | H | Tottenham Hotspur | 1-0 | Lyons. |
| 18/03/06 | A | Birmingham City | 4-1 | Grabban 4. |
| 25/03/06 | H | Arsenal | 2-2 | Hughes. Grabban. |
| 01/04/06 | H | Bristol City | 1-3 | Sheringham. |
| 08/04/06 | A | Cardiff City | 1-0 | Grabban. |
| 22/04/06 | H | Watford | 1-1 | Wiggins. |
| 29/04/06 | A | Charlton Athletic | 4-1 | Spence 2. Grabban. Kudjodi. |